iBioTUM
TUM School of Medicine and Health
Technical University of Munich

Molecular pathology, an innovative field of medicine, is opening new doors to deeper insights. It works with three different types of tissues: FFPE tissue, frozen tissue, and PAXgene tissue.

FFPE tissue - that is, formalin-fixed tissue embedded in kerosene - is a workhorse of molecular pathology. It enables the isolation of DNA and RNA, the basic building blocks of our genetic information. It can also isolate protein and phosphoprotein, which play key roles in signal transduction in our cells.

Frozen tissue is another important source for molecular pathology. These are freshly collected tissues that are frozen immediately after collection to preserve their natural structure and composition. DNA, RNA, and proteins/phosphoproteins can also be isolated from these samples, making this technique an important tool for disease research.

Last but not least, the PAXgene Tissue plays an important role. This special tissue system allows formalin-free fixation, enabling the isolation of unmodified genetic material. DNA, RNA, and proteins/phosphoproteins are isolated, which can then be studied in detail.

All these different tissues and methods contribute to the fact that molecular pathology is getting better and better, giving us deeper and deeper insights into the complex processes in the human body.